Groupe d'Etude en Oncologie du Quebec

Title	A Pilot Study of Two Dose Escalation Strategies to Increase the Population of Complete Responders After Radiation Therapy in Rectal Cancer Patients.
Protocole ID	Morpheus study (no surgery)
ClinicalTrials.gov ID	NCT03051464
Cancer Type(s)	Colon and Rectum
Phase
Stage
Study Type	Clinical
Drug
Institution	CIUSSS DU CENTRE-OUEST-DE-L'ILE-DE-MONTREAL HOPITAL GENERAL JUIF SIR MORTIMER B.DAVIS 3755 rue de la Côte Ste. Catherine, Montréal, QC, H3T 1E2
City	Montréal
Principal Investigator	Dr. Té Vuong
Coordinator	Emma Starr 514-340-8222 poste 28443
Status	Recruiting
Activation Date
Eligibility Criteria	Rectal cancer patients, clinically staged as T2-T3 by MRI or endoscopic/trans-rectal ultrasound Rectal cancer staged as N0-N1 by MRI or EUS/TRUS No metastatic lesion Rectal tumor occupying less than half of the circumference Tumor less than 5 cm on its largest dimension Tumor located at less than 10 cm from the anal verge Tumor penetration less than 5 mm in the mesorectal fat Tumor accessible for brachytherapy Lumen accessible for colonoscopy Patient should be a suitable candidate for brachytherapy and chemotherapy Older than 18 years of age Adequate birth control measures in women of childbearing potential Written informed consent
Exclusion Criteria	Patients with previous pelvic radiation Evidence of distant metastasis Extension of malignant disease to the anal canal Tumors staged as T4 Tumors larger than 5 cm in length

Groupe d'étude en oncologie du Québec